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Updated: May 8, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Meningococcal disease.

Ziad A Memish¹, Abdulrahman A Alrajhi

¹Department of Medicine and Infection Prevention and Control, King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia.

Neurosciences (Riyadh, Saudi Arabia)

|August 28, 2013

Summary

Meningococcal disease, caused by Neisseria meningitidis, presents significant risks globally. Updated vaccination strategies, including quadrivalent vaccines, are crucial for preventing outbreaks and reducing mortality from this serious infection.

Area of Science:

Epidemiology
Infectious Diseases
Vaccinology

Background:

Meningococcal disease, caused by Neisseria meningitidis, is a major global health concern with high morbidity and mortality.
Serogroups A, B, and C historically dominate, but recent epidemiological shifts show increased prevalence of serogroups C, Y, and W135 in various regions.

Purpose of the Study:

To analyze the changing epidemiology of meningococcal disease.
To highlight the impact of Neisseria meningitidis serogroup W135 emergence in Saudi Arabia.
To discuss updated vaccination policies and treatment strategies.

Main Methods:

Review of epidemiological data on Neisseria meningitidis serogroups.
Analysis of outbreak patterns, particularly during Hajj seasons.

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Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

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Last Updated: May 8, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Published on: May 7, 2020

Evaluation of current and developing prevention and treatment guidelines.

Main Results:

Serogroup W135 emergence in Saudi Arabia caused significant outbreaks during Hajj seasons.
Vaccine requirements were updated to include quadrivalent (A, C, Y, W135) vaccines.
Meningococcal disease mortality remains high (5-10%) despite advances.

Conclusions:

Targeted vaccination strategies based on regional epidemiology are essential.
Rapid chemoprophylaxis for close contacts is a key preventive measure.
Development of new conjugate vaccines (e.g., quadrivalent) is ongoing and critical.