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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Neuromyelitis optica
Haga A Kargwell1, Waleed A Khoja, Basim A Yaqub
1Department of Neurosciences, Armed Forces Hospital, PO Box 7897, Riyadh 11159, Kingdom of Saudi Arabia. Tel. +966 (1) 4777714 ext. 5419/5329. Fax. +966 (1) 4777194. E-mail: hkargwell@hotmail.com or rkhnsksa@zajil.net.
Abstract:
Neuromyelitis optica disease is characterized by simultaneous or successive attacks involving both the optics nerves and spinal cord without any evidence of the disease elsewhere. We report a 22-year-old Saudi woman with relapsing neuromyelitis optica disease. She had all the clinical, cerebrospinal fluid, and radiological features that differ from primary demyelinating disease. However, our patient responded well to long-term corticosteroid therapy and azathioprine with improvement in her expanded disability status scale, and ambulation. In addition, no acute relapses occurred with significant improvement on magnetic resonance imaging lesions and favorable outcome.
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