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Related Experiment Video

Updated: May 8, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Neuromyelitis optica.

Haga A Kargwell1, Waleed A Khoja, Basim A Yaqub

  • 1Department of Neurosciences, Armed Forces Hospital, PO Box 7897, Riyadh 11159, Kingdom of Saudi Arabia. Tel. +966 (1) 4777714 ext. 5419/5329. Fax. +966 (1) 4777194. E-mail: hkargwell@hotmail.com or rkhnsksa@zajil.net.

Neurosciences (Riyadh, Saudi Arabia)
|August 28, 2013
PubMed
Summary

Neuromyelitis optica disease, a condition affecting the optic nerves and spinal cord, was effectively managed in a Saudi woman. Long-term treatment with corticosteroids and azathioprine led to significant recovery and prevented relapses.

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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Area of Science:

  • Neurology
  • Immunology

Background:

  • Neuromyelitis optica disease (NMO) involves attacks on the optic nerves and spinal cord.
  • Distinguishing NMO from other demyelinating diseases is crucial for appropriate treatment.

Purpose of the Study:

  • To report a case of relapsing Neuromyelitis optica disease in a young Saudi woman.
  • To highlight the clinical, cerebrospinal fluid, and radiological features differentiating it from primary demyelinating diseases.
  • To evaluate the long-term treatment response and outcome.

Main Methods:

  • Clinical assessment of a 22-year-old Saudi female patient with suspected NMO.
  • Analysis of cerebrospinal fluid and radiological (MRI) findings.
  • Long-term therapeutic intervention using corticosteroids and azathioprine.

Main Results:

  • The patient presented with features distinct from primary demyelinating diseases.
  • Significant improvement was observed in the Expanded Disability Status Scale and ambulation.
  • No acute relapses occurred during the treatment period.
  • Magnetic resonance imaging showed improvement in lesions.

Conclusions:

  • Long-term corticosteroid and azathioprine therapy can be effective in managing relapsing Neuromyelitis optica disease.
  • This treatment approach can lead to favorable outcomes, including reduced disability and lesion burden.
  • Early diagnosis and sustained management are key for patients with NMO.