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Related Concept Videos

Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is covered...
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...

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Updated: May 8, 2026

In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye
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In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye

Published on: March 29, 2024

Liver in a dish.

Qiurong Ding1, Chad A Cowan

  • 1Department of Stem Cell and Regenerative Biology, Harvard University, Sherman Fairchild Biochemistry Bldg 153, 7 Divinity Ave, Cambridge, MA 02138, USA.

Cell Research
|August 28, 2013
PubMed
Summary
This summary is machine-generated.

Scientists grew functional liver organoids from stem cells, potentially solving the global donor liver shortage. This breakthrough offers hope for future liver transplantation needs.

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In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
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In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

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Optimized and Simplified Technique for the Production and Culture of Precision-Cut Liver Slices
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Optimized and Simplified Technique for the Production and Culture of Precision-Cut Liver Slices

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Related Experiment Videos

Last Updated: May 8, 2026

In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye
05:27

In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye

Published on: March 29, 2024

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

Optimized and Simplified Technique for the Production and Culture of Precision-Cut Liver Slices
06:00

Optimized and Simplified Technique for the Production and Culture of Precision-Cut Liver Slices

Published on: November 22, 2024

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Organogenesis

Background:

  • A critical worldwide shortage of donor livers for transplantation exists.
  • This scarcity significantly limits treatment options for patients with end-stage liver disease.

Purpose of the Study:

  • To investigate the potential of stem cells to generate functional liver tissue.
  • To address the critical need for alternative sources of liver grafts for transplantation.

Main Methods:

  • Generation of three-dimensional liver organoids (liver buds) from induced pluripotent stem cells (iPSCs).
  • Cultivation of liver buds in vitro to promote self-organization and maturation.
  • Assessment of liver-specific functions, including bile acid transport and albumin secretion.

Main Results:

  • Successfully generated functional liver buds from iPSCs in a laboratory setting.
  • Demonstrated the presence of key hepatocyte and cholangiocyte lineages within the organoids.
  • Observed essential liver functions, indicating the potential for therapeutic application.

Conclusions:

  • Stem cell-derived liver buds represent a promising alternative to donor livers.
  • This advancement could revolutionize liver transplantation and the treatment of liver diseases.