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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

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Related Experiment Video

Updated: May 8, 2026

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

Metronomic therapy: chemotherapy revisited.

V Noronha1, M V Krishna, V Patil

  • 1Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Indian Journal of Cancer
|August 28, 2013
PubMed
Summary

Metronomic chemotherapy, using low doses frequently, may improve cancer treatment outcomes. This approach aims to reduce tumor regrowth and resistance compared to traditional chemotherapy schedules.

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Last Updated: May 8, 2026

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Published on: May 14, 2016

Area of Science:

  • Oncology
  • Cancer Therapeutics
  • Pharmacology

Background:

  • Standard chemotherapy schedules can lead to tumor regrowth and drug resistance.
  • Current chemotherapy outcomes are stagnating for many cancer types.
  • High-dose chemotherapy causes significant toxicity and long-term side effects.

Purpose of the Study:

  • To review the biological rationale behind metronomic chemotherapy.
  • To examine the existing evidence supporting metronomic chemotherapy.
  • To explore an alternative chemotherapy administration strategy.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of biological mechanisms of metronomic scheduling.
  • Synthesis of data on efficacy and toxicity.

Main Results:

  • Metronomic chemotherapy demonstrates anti-angiogenic and immunomodulatory effects.
  • Studies show potential for reduced toxicity and improved efficacy in certain cancers.
  • Evidence suggests metronomic scheduling can overcome resistance mechanisms.

Conclusions:

  • Metronomic chemotherapy offers a promising alternative to conventional dosing.
  • Further clinical trials are warranted to establish its role in cancer treatment.
  • This strategy may enhance patient outcomes and reduce treatment burden.