Related Experiment Video
Updated: May 8, 2026

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Stability of succinylcholine chloride injection at ambient temperature and 4 deg C in polypropylene syringes
Meredith L Storms1, James T Stewart, Flynn W Warren
1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.
Abstract:
The stability of 20-mg/mL succinylcholine chloride injection in 12-mL polypropylene syringes stored at ambient temperature and 4 deg C for up to 90 days was investigated. Concentration levels of succinylcholine chloride injection were determined at 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes by means of a high-performance liquid chromatographic stability-indicating assay. Methylparaben, which was added as a preservative, did not interfere with the assay. The loss in potency was less than 10% after 45 days of storage at 25 deg C and less than 1% after 90 days of storage at 4 deg C. The pH of succinylcholine chloride injection did not change appreciably during the 90-day study period.
Related Concept Videos
Depolarizing Blockers: Pharmocokinetics
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Drug Product Stability
Polymer Classification: Stereospecificity
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Depolarizing Blockers: Mechanism of Action
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because succinylcholine...
