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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Lineage Commitment01:21

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Commitment is the  process whereby stem cells:
Hematopoiesis01:21

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Updated: May 8, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

Clonal evolution in hematological malignancies and therapeutic implications.

D A Landau1, S L Carter2, G Getz3

  • 11] Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA, USA [2] Broad Institute, Cambridge, MA, USA [3] Department of Hematology, Yale Cancer Center, New Haven, CT, USA [4] Université Paris Diderot, Paris, France.

Leukemia
|August 28, 2013
PubMed
Summary
This summary is machine-generated.

Cancer evolves through genetically diverse cell groups, challenging targeted therapies. Understanding this clonal evolution, accelerated by treatment, is key to developing new cancer treatments and prognostics.

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Last Updated: May 8, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

Area of Science:

  • Oncology
  • Evolutionary Biology
  • Genetics

Background:

  • Cancer's adaptability poses a significant challenge to effective treatment.
  • Tumors comprise genetically heterogeneous subpopulations driving this evolution.
  • Darwinian selection shapes the tumor's genetic landscape over time.

Purpose of the Study:

  • To investigate the evolutionary dynamics of cancer, particularly in hematological malignancies.
  • To understand how genetic heterogeneity and clonal evolution impact therapeutic resistance.
  • To explore the reciprocal relationship between cancer treatment and tumor evolution.

Main Methods:

  • Utilized massively parallel sequencing to analyze tumor genetic landscapes.
  • Integrated findings with previous cytogenetic and targeted sequencing studies.
  • Examined evolutionary trajectories across various hematological malignancies.

Main Results:

  • Confirmed complex evolutionary trajectories in hematological cancers.
  • Demonstrated that clonal evolution contributes to therapeutic resistance.
  • Observed that cancer treatments can accelerate tumor evolution.

Conclusions:

  • Cancer's evolutionary capacity, driven by clonal heterogeneity, is a major therapeutic hurdle.
  • Treatment can paradoxically hasten cancer's adaptive evolution.
  • Further research is needed to leverage insights into clonal evolution for novel prognostic and therapeutic strategies.