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Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
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Genome-wide analyses of borderline personality features.

G H Lubke1, C Laurin2, N Amin3

  • 11] University of Notre Dame, Notre Dame, IN, USA [2] VU University Amsterdam, Amsterdam, The Netherlands.

Molecular Psychiatry
|August 28, 2013
PubMed
Summary
This summary is machine-generated.

Genetic studies reveal borderline personality (BP) features have 23% heritability. A specific gene, SERINC5, linked to myelination, shows a promising association with BP, particularly affect instability.

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Area of Science:

  • Psychiatry
  • Genetics
  • Neuroscience

Background:

  • Heritability of borderline personality (BP) features is well-established through twin and family studies.
  • Previous research indicates a genetic component to BP traits, but specific genetic underpinnings require further investigation.

Purpose of the Study:

  • To estimate the heritability of BP features using genome-wide single-nucleotide polymorphism (SNP) data.
  • To conduct the first genome-wide association study (GWAS) for BP features and identify associated genetic loci.
  • To explore the genetic heterogeneity across different facets of BP features.

Main Methods:

  • Utilized data from two large Dutch cohorts (N=7125) from the Netherlands Twin Register and The Netherlands Study of Depression and Anxiety.
  • Calculated heritability of the Personality Assessment Inventory Borderline Features Scale (PAI-BOR) total score and subscales using genome-wide SNP data.
  • Performed a GWAS for BP features and validated findings in an independent cohort (N=1301).

Main Results:

  • Heritability of the PAI-BOR total score was estimated at 23%.
  • Genetic variance was significantly higher for affect instability items (42.7%) compared to self-harm, negative relations, and identity problems.
  • A promising GWAS signal was identified on chromosome 5, corresponding to SERINC5, a gene involved in myelination, and confirmed in an independent cohort.
  • SNP associations with SERINC5 varied across PAI-BOR items and were primarily observed in individuals with higher BP scores.

Conclusions:

  • Genome-wide analyses of BP features demonstrate significant heritability and highlight genetic heterogeneity across symptom clusters.
  • SERINC5 emerges as a potential genetic locus associated with BP features, particularly affect instability, suggesting a role for myelination.
  • Future GWAS studies on BP features should consider phenotypic and genetic heterogeneity for enhanced discovery.