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[Research progression in tumor-infiltration lymphocytic cells in colorectal cancer]

Zhi-wei Zhai1, Zhen-jun Wang

  • 1Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. wang3zj@sohu.com.

Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery
|August 28, 2013
PubMed

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...