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Updated: May 8, 2026
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Inhaled cisplatin deposition and distribution in lymph nodes in stage II lung cancer patients
Paul Zarogoulidis1, Kaid Darwiche, Leslie Krauss
1Pulmonary Department Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. pzarog@hotmail.com
Abstract:
Lung cancer therapies during the last decade have focused on targeting the genome of cancer cells, and novel routes for administering lung cancer therapies have been investigated for decades. Aerosol therapies for several systematic diseases and systemic infections were introduced into the market a decade ago. One of the main issues of aerosol therapies has been the ability to investigate the deposition of a drug compound throughout the systematic circulation and lymph node circulation. Until now, none of the published studies have efficiently shown the deposition of a chemotherapy pharmaceutical within the lymph node tissue. In our current work we present, for the first time, with the novel CytoViva(®) (AL, USA) technique, the deposition of cisplatin aerosol therapy in surgically resected stage II lymph nodes from lung cancer patients. Finally, we present the distribution of cisplatin in correlation with the cisplatin concentration in different lymph stations and comment on the possible mechanisms of distribution.
Insights
This study demonstrates, for the first time, the deposition of cisplatin aerosol therapy in lung cancer patient lymph nodes. The novel CytoViva technique visualizes chemotherapy distribution within lymph node tissue, aiding future lung cancer treatment strategies.
Area of Science:
- Oncology
- Pharmacology
- Nanotechnology
Background:
- Lung cancer treatment increasingly targets cancer cell genomes.
- Aerosol drug delivery offers a novel administration route for systemic diseases.
- Investigating drug deposition in lymph nodes is crucial for effective chemotherapy.
Purpose of the Study:
- To visualize and quantify cisplatin aerosol deposition in lymph node tissue from lung cancer patients.
- To present the distribution of cisplatin within different lymph node stations.
- To correlate drug concentration with distribution patterns and explore potential distribution mechanisms.
Main Methods:
- Utilized the novel CytoViva technique for imaging.
- Analyzed surgically resected stage II lymph nodes from lung cancer patients.
- Quantified cisplatin concentration and distribution in various lymph stations.
Main Results:
- Successfully demonstrated cisplatin aerosol deposition within lymph node tissue for the first time.
- Visualized the distribution of cisplatin across different lymph node stations.
- Established a correlation between cisplatin concentration and its distribution patterns.
Conclusions:
- The CytoViva technique enables visualization of chemotherapy deposition in lymph nodes.
- Findings provide insights into cisplatin distribution mechanisms in lung cancer patients.
- This research paves the way for optimized aerosol-based lung cancer therapies.
