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Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...

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Related Experiment Video

Updated: May 8, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Tissue engineering and regeneration of lymphatic structures.

Evan Weitman1, Daniel Cuzzone, Babak J Mehrara

  • 1The Department of Surgery, Plastic Surgery Section, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Future Oncology (London, England)
|August 29, 2013
PubMed
Summary

Tissue engineering reconstructs biological tissues using cells and scaffolds. Recent progress in lymphatic tissue engineering leverages new insights into lymphatic development and function for therapeutic applications.

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Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
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Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Related Experiment Videos

Last Updated: May 8, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Immunology

Background:

  • Tissue engineering aims to regenerate damaged tissues using cells, signals, and scaffolds.
  • In vivo applications face challenges, but progress is evident across organ systems.
  • The lymphatic system is crucial for immunity, inflammation, and fluid balance.

Purpose of the Study:

  • This review focuses on advancements in lymphatic tissue engineering.
  • It highlights the application of recent biological insights to this field.

Main Methods:

  • Review of current literature on lymphatic system development and function.
  • Analysis of tissue engineering strategies applied to lymphatic structures.

Main Results:

  • Significant progress has been made in engineering lymphatic tissues.
  • Understanding of lymphatic development and function has driven these advancements.

Conclusions:

  • Lymphatic tissue engineering holds promise for treating lymphatic-related disorders.
  • Continued research integrating biological insights is key for future success.