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An oral multiparticulate, modified-release, hydrocortisone replacement therapy that provides physiological cortisol

Martin Whitaker1, Miguel Debono1, Hiep Huatan1

  • 1Academic Unit of Diabetes, Endocrinology and Reproduction, University of Sheffield, Sheffield, UK (M.D., R.J.R); Diurnal Ltd, Cardiff, UK (M.W., H.H.); National Institutes of Health Clinical Center and The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA (D.M.); Centre for Endocrinology, Diabetes and Metabolism, School of Clinical & Experimental Medicine, University of Birmingham, Birmingham, UK (W.A.).

Clinical Endocrinology
|August 29, 2013
PubMed
Summary

New hydrocortisone formulations using multiparticulate technology successfully mimic physiological cortisol profiles in adrenal insufficiency patients. This breakthrough offers improved cortisol replacement therapy by replicating natural diurnal rhythms.

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