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Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Total synthesis of the tetracyclic lupin alkaloid (+)-allomatrine
Samuel V Watkin1, Nicholas P Camp, Richard C D Brown
1Department of Chemistry, The University of Southampton, Highfield, Southampton SO17 1BJ, UK.
Organic Letters
|August 29, 2013
Abstract:
(+)-Allomatrine (1) has been synthesized using an imino-aldol reaction and N-acyliminium cyclization as key steps. Strategically, use of the tert-butylsulfinimine derivative of (E)-4-(trimethylsilyl)but-2-enal enabled the staged formation of three C-C bonds, a C-N bond, and the four stereogenic centers within the target.
