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Updated: May 8, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Salmonella mycotic thoracoabdominal aortic aneurysm associated with chronic lymphocytic leukemia

Michal Tomek1, Nicholas J W Cheshire, Nung Rudarakanchana

  • 1Imperial Vascular Unit, St. Mary's Hospital, Imperial College London, London, UK.

Annals of Vascular Surgery
|August 29, 2013
PubMed

Insights

A rare Salmonella enteritidis infection caused a severe aortic aneurysm and spinal infection in a chronic lymphocytic leukemia (CLL) patient. This case highlights potential immune defects in CLL, even with normal counts, predisposing to invasive bacterial infections.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Vascular Surgery

Background:

  • Non-typhoidal Salmonella typically causes gastroenteritis.
  • Extraintestinal Salmonella infections can lead to severe focal disease, such as mycotic aneurysms.

Observation:

  • A 71-year-old man with chronic lymphocytic leukemia (CLL) presented with a type V thoracoabdominal mycotic aneurysm.
  • The aneurysm was infected with Salmonella enteritidis and complicated by spondylodiscitis, paravertebral collections, and epidural abscess.

Findings:

  • This is the first reported case of Salmonella aortitis in a patient with CLL.
  • The extensive local invasion suggests CLL-related immunosuppression as a potential predisposing factor.

Implications:

  • Highlights the need to consider immune defects in CLL patients, even with normal leukocyte counts.
  • Suggests impaired cell-mediated immunity may increase susceptibility to invasive Salmonella infections in CLL.

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