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Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: May 8, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Chronic inflammation and gallbladder cancer.

Yumin Li1, Junqiang Zhang1, Haizhen Ma2

  • 1The Second Hospital of Lanzhou University, Lanzhou 730030, China; Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou 730030, China.

Cancer Letters
|August 29, 2013
PubMed
Summary

Chronic inflammation, often from gallbladder infections or gallstones, significantly increases gallbladder cancer (GBC) risk. This review explores how inflammation drives GBC development by causing genetic changes and promoting tumor growth.

Keywords:
AetiologyChronic inflammationGallbladder cancerPathogenesis

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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Published on: June 28, 2021

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Last Updated: May 8, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Gallbladder cancer (GBC) is a prevalent biliary tract malignancy with a poor prognosis.
  • Chronic inflammation from gallbladder infections or gallstones is a known risk factor for GBC.
  • Emerging research is clarifying the molecular pathways linking chronic inflammation to GBC development.

Purpose of the Study:

  • To review the current understanding of chronic inflammation's role in gallbladder tumorigenesis.
  • To elucidate the molecular mechanisms by which inflammation contributes to GBC progression.

Main Methods:

  • Literature review of recent studies on inflammation and GBC.
  • Analysis of molecular mechanisms involved in chronic inflammation-induced gallbladder cancer.

Main Results:

  • Persistent local inflammatory reactions can drive GBC development.
  • Inflammation may induce genetic alterations, promoting mutated cell survival and proliferation.
  • Inflammatory processes can also inhibit apoptosis, stimulate angiogenesis, and promote metastasis.

Conclusions:

  • Chronic inflammation is a key factor in gallbladder tumorigenesis.
  • Understanding these inflammatory mechanisms is crucial for GBC prevention and treatment strategies.