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Related Experiment Video

Updated: May 8, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

HIV, aging, and cognition: emerging issues.

Victor G Valcour¹

¹Department of Neurology, Division of Geriatric Medicine, University of California San Francisco, San Francisco, CA, USA.

Topics in Antiviral Medicine

|August 29, 2013

Summary

This summary is machine-generated.

HIV-associated neurocognitive disorder remains prevalent at 50%, with mild neurocognitive disorder more common than dementia. Age and specific genetic factors like ApoE4 influence cognitive impairment in older adults on antiretroviral therapy.

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Published on: July 24, 2013

Area of Science:

Neuroscience
Infectious Diseases
Geriatrics

Background:

HIV-associated neurocognitive disorder (HAND) prevalence remains high at 50% despite potent antiretroviral therapy (ART).
Mild neurocognitive disorder (MND) and asymptomatic neurocognitive impairment (ANI) are now more frequent than HIV-associated dementia.
The distinction between ANI and MND is often blurred due to comparable functional deficits and neuropsychological testing abnormalities.

Purpose of the Study:

To examine correlates of cognitive impairment in older adults with HIV.
To investigate the impact of age-related comorbidities on cognitive function in HIV-infected individuals.
To inform management strategies for cognitive impairment in the context of effective ART.

Main Methods:

Analysis of a cohort of patients aged 60 years or older with excellent ART adherence.
Assessment of cognitive impairment using neuropsychological testing.
Evaluation of correlates including apolipoprotein (Apo) E4 genotype, monocyte efficacy (ME) score, diabetes, and nadir CD4+ cell count.

Main Results:

Apolipoprotein (Apo) E4 genotype and monocyte efficacy (ME) score were significant correlates of cognitive impairment in older adults with HIV.
Diabetes and nadir CD4+ cell count showed trend associations with cognitive impairment.
Age-related comorbidities exacerbate cognitive impairment risk in HIV-infected individuals.

Conclusions:

Cognitive impairment in older adults with HIV is associated with ApoE4 genotype and ART effectiveness at the cellular level (ME score).
Management should focus on optimizing ART, adherence, and addressing comorbidities like diabetes.
Switching ART for mild cognitive impairment is generally not recommended but requires individualized assessment.