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Stability of Ephedrine Sulfate at Ambient Temperature and 4 deg C in Polypropylene Syringes
M L Storms1, J T Stewart, F W Warren
1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, Georgia.
Abstract:
The stability of 5 mg/mL ephedrine sulfate in 0.9% sodium chloride in 10-mL polypropylene syringes stored at ambient temperature and at 4 deg C for up to 60 days was investigated. Concentration levels of ephedrine sulfate were determined by means of a high-performance liquid chromatography stability-indicating assay at 0, 1, 4, 7, 14, 30, 45 and 60 days after preparation of the syringes. Benzyl alcohol, which was added as a preservative, did not interfere with the assay. The injections in polypropylene syringes were stable for up to 60 days at both ambient temperature and at 4 deg C. The pH of the ephedrine sulfate injections did not change appreciably in a particular direction during the 60-day study period. These data support the stability of ephedrine sulfate under the storage conditions investigated in this study.
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