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Cross-contamination in Porcelain Mortars.

A Bauer-Brandl¹, A Falck, L Ingebrigtsen

¹Institute of Pharmacy, Unviversity of Tromso, Tromso, Norway.

International Journal of Pharmaceutical Compounding

|August 29, 2013

Summary

This summary is machine-generated.

Drug residues on porcelain mortars are difficult to remove, posing cross-contamination risks. Plastic mortars offer a cleaner alternative for drug comminution, though both are suitable for suspension ointments.

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Porcelain mortars and pestles are widely used for small-scale drug comminution.
Concerns exist regarding drug residue removal and cross-contamination from rough mortar surfaces.

Purpose of the Study:

To quantify residual drug amounts on porcelain versus plastic mortars after washing.
To compare the quality of suspension ointments prepared using both mortar types.

Main Methods:

Salicylic acid residue on porcelain and plastic mortars was measured after various washing procedures.
Particle size and homogeneity of suspension ointments were assessed.

Main Results:

Significant drug residues (in the mg range) remained on porcelain mortars, indicating inadequate cleaning.
No drug traces were detected on plastic mortars.
Both porcelain and plastic mortars yielded comparable suspension ointment quality.

Conclusions:

Standard rinsing procedures are insufficient for effectively cleaning porcelain mortars.
Plastic mortars present a superior option for minimizing drug cross-contamination.
Both materials are suitable for preparing semisolid suspensions.