Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroimaging findings in Alexander's disease.

G B Bobele1, A Garnica, G B Schaefer

  • 1Department of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73126.

Journal of Child Neurology
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Index of suspicion. Case 3. Diagnosis: septic arthritis.

Pediatrics in review·2001
Same author

Prognostic value of magnetic resonance imaging in the management of fistula-in-ano.

Diseases of the colon and rectum·2000
Same author

Dual phase hepatic CT: influence of scanning direction on liver attenuation.

AJR. American journal of roentgenology·2000
Same author

Parents' experiences of general hospital admission for adults with learning disabilities.

Journal of clinical nursing·2000
Same author

Conformational transitions in model silk peptides.

Biophysical journal·2000
Same author

Equine vaccination.

Journal of veterinary internal medicine·2000
Same journal

Assessing Sudden Unexpected Death in Epilepsy (SUDEP), Mortality, and Suicide in Pediatric Epilepsy from the lens of Healthcare Disparities: Data From a Scoping Review.

Journal of child neurology·2026
Same journal

The Importance of Accessible, Patient-Focused Language in the Age of the Electronic Medical Record.

Journal of child neurology·2026
Same journal

Genetic Etiologies and Risk Factors for Regressive Autism and Childhood Disintegrative Disorder: A Scoping Review.

Journal of child neurology·2026
Same journal

Birmingham, 1963.

Journal of child neurology·2026
Same journal

Hyperintensity on Diffusion-Weighted Imaging in a MELAS Patient Does Not Necessarily Mean Cytotoxic Edema.

Journal of child neurology·2026
Same journal

Neuromuscular Symptoms of <i>ORAI1</i>-Related Immunodeficiency.

Journal of child neurology·2026
See all related articles

This study details imaging findings in a child with Alexander's disease, revealing widespread white matter abnormalities and reduced brain metabolism, especially in frontal regions.

Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Genetic Neurological Disorders

Background:

  • Alexander's disease is a rare, progressive, and fatal leukoencephalopathy.
  • Diagnosis often relies on clinical presentation and neuroimaging findings.

Observation:

  • A 2-year-old girl with Alexander's disease underwent comprehensive neuroimaging.
  • Imaging modalities included magnetic resonance imaging (MRI), computed tomographic (CT) scan, and single photon emission computed tomography (SPECT).

Findings:

  • CT scans demonstrated significant low-density white matter in the cerebral hemispheres.
  • MRI revealed increased T2 signal in cerebral white matter, sparing the cerebellum and brain stem.
  • SPECT indicated reduced cerebral metabolism, most notably in the frontal lobes compared to the cerebellum.

Related Experiment Videos

Implications:

  • These imaging findings contribute to the understanding of Alexander's disease pathophysiology.
  • Neuroimaging plays a crucial role in diagnosing and monitoring this rare leukoencephalopathy.
  • Further research can correlate imaging biomarkers with disease progression and treatment efficacy.