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Related Experiment Video

Updated: May 8, 2026

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy
08:54

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy

Published on: June 5, 2019

Molecular plasmonics for nanoscale spectroscopy.

Matthew D Sonntag1, Jordan M Klingsporn, Alyssa B Zrimsek

  • 1Northwestern University, Department of Chemistry, 2145 Sheridan Road, Evanston, IL 60208, USA. vanduyne@northwestern.edu.

Chemical Society Reviews
|August 29, 2013
PubMed
Summary

Surface- and tip-enhanced Raman and localized surface plasmon resonance (LSPR) spectroscopies reveal single-molecule and single-particle properties. These techniques offer insights into molecular distributions and local environments beyond ensemble measurements.

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Area of Science:

  • Spectroscopy
  • Nanotechnology
  • Physical Chemistry

Background:

  • Surface- and tip-enhanced Raman spectroscopy (TERS) and localized surface plasmon resonance (LSPR) spectroscopy have emerged as powerful techniques.
  • These methods enable the study of properties at the single-molecule and single-particle level.
  • Ensemble measurements often obscure unique characteristics observable at the individual event level.

Purpose of the Study:

  • To review major developments in single-molecule and single-particle Raman and LSPR spectroscopy.
  • To highlight key applications of these advanced spectroscopic techniques.
  • To discuss the insights gained from studying individual events compared to ensemble measurements.

Main Methods:

  • Surface-enhanced Raman spectroscopy (SERS)

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Last Updated: May 8, 2026

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy
08:54

Performing Spectroscopy on Plasmonic Nanoparticles with Transmission-Based Nomarski-Type Differential Interference Contrast Microscopy

Published on: June 5, 2019

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
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Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

  • Tip-enhanced Raman spectroscopy (TERS)
  • Localized surface plasmon resonance (LSPR) spectroscopy

    • Main Results:

    • Single-molecule and single-particle spectroscopies provide access to property distributions not seen in ensemble averages.
    • Raman spectroscopy offers detailed molecular identification.
    • LSPR spectroscopy provides information on the local environment.

    Conclusions:

    • Single-molecule and single-particle Raman and LSPR spectroscopies are invaluable tools for nanoscale investigations.
    • These techniques significantly advance our understanding of molecular and material properties.
    • Continued development promises further breakthroughs in nanoscience and spectroscopy.