Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Musculoskeletal Pain in Surgeons on Operating Days.

The American surgeon·2026
Same author

Fine Particulate Matter, Its Constituents, and Spontaneous Preterm Birth.

JAMA network open·2024
Same author

Fertility and Pregnancy Outcomes in Primary Hyperparathyroidism: Observations From a Large Insured Population.

The Journal of clinical endocrinology and metabolism·2024
Same author

Lessons from the American Association of Endocrine Surgeons (AAES) ergonomics panel: Operating is a pain in the neck … and other places.

American journal of surgery·2024
Same author

Adenomyosis in women undergoing hysterectomy for abnormal uterine bleeding associated with uterine leiomyomas.

PloS one·2023
Same author

Analysis of Heat Exposure During Pregnancy and Severe Maternal Morbidity.

JAMA network open·2023
Same journal

Mapping Plastic Reconstructive Surgical Needs and Access Barriers in Sub-Saharan Africa: A Scoping Review.

World journal of surgery·2026
Same journal

Correction to "Guidelines for Essential Trauma Care: Second Edition (2026)".

World journal of surgery·2026
Same journal

Assessing the Burden of Operatively Managed Extremity Fractures in Malawi: A Tale of Two Tertiary Hospitals.

World journal of surgery·2026
Same journal

The Impact of Obesity on Intraoperative, Oncological, and Postoperative Endpoints in Robotic Pancreaticoduodenectomy.

World journal of surgery·2026
Same journal

Prediction Models for Sentinel Lymph Node Metastasis in Clinically Node-Negative Breast Cancer: Validation of Existing Nomograms, Model Development, and Ensemble Evaluation.

World journal of surgery·2026
Same journal

Indicators for Monitoring Recovery From Surgery to Discharge Using Accelerometer in Patients With Esophageal Cancer.

World journal of surgery·2026
See all related articles

Related Experiment Video

Updated: May 8, 2026

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

Hypothyroidism after hemithyroidectomy.

Meena Said1, Vicki Chiu, Philip I Haigh

  • 1Department of Surgery, Mount Sinai Hospital, One Gustave L. Levy Place, New York, NY, 10029, USA, meena.said@mountsinai.org.

World Journal of Surgery
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

About one third of patients develop hypothyroidism after hemithyroidectomy. Higher preoperative thyroid stimulating hormone (TSH) levels significantly predict this risk, aiding in patient counseling.

More Related Videos

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

Related Experiment Videos

Last Updated: May 8, 2026

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Public Health

Background:

  • Post-hemithyroidectomy hypothyroidism risk estimates vary, often from single institutions.
  • Population-level incidence and predictive factors remain incompletely understood.

Purpose of the Study:

  • To determine the population-level incidence of hypothyroidism after hemithyroidectomy.
  • To identify independent predictors of hypothyroidism in euthyroid patients undergoing hemithyroidectomy.

Main Methods:

  • Retrospective analysis of 1,240 euthyroid patients undergoing hemithyroidectomy for benign disease (2000-2010).
  • Analysis of hypothyroidism incidence (TSH >4 μIU/ml) and evaluation of age, gender, race, thyroiditis, and preoperative TSH as predictors.

Main Results:

  • 34% of patients developed hypothyroidism; 25% required levothyroxine.
  • Increased risk observed with higher age quartiles and presence of thyroiditis.
  • Preoperative TSH level was a significant predictor, with risk increasing substantially as levels approached 4 μIU/ml (OR=45.1 for TSH 3.01-4 vs <1 μIU/ml).

Conclusions:

  • Approximately one-third of euthyroid patients develop hypothyroidism post-hemithyroidectomy.
  • Preoperative TSH level is the strongest predictor, with risk escalating with higher baseline levels.
  • A simple categorical scale based on preoperative TSH can aid in patient counseling.