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Related Experiment Video

Updated: May 8, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
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Sensorimotor development in neonatal progesterone receptor knockout mice.

Jari Willing1, Christine K Wagner

  • 1Department of Psychology, University at Albany - SUNY, Albany, New York.

Developmental Neurobiology
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

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Early progesterone receptor (PR) expression in the developing cortex is crucial. PR knockout mice show altered sensorimotor development, indicating PR

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Endocrinology

Background:

  • Steroid hormones significantly influence neural development, particularly in reproductive and neuroendocrine brain regions.
  • Emerging evidence highlights steroid hormones' role in shaping cognitive brain areas like the cerebral cortex.
  • The progesterone receptor (PR) is highly expressed in the developing rodent cortex during critical maturation periods.

Purpose of the Study:

  • To investigate progesterone receptor (PR) expression in the neonatal mouse somatosensory cortex.
  • To examine the role of PR in cortical development by assessing sensorimotor function in PR knockout mice.

Main Methods:

  • Investigated PR expression in neonatal mouse somatosensory cortex.
  • Assessed sensorimotor function in progesterone receptor knockout (PRKO), heterozygous (HZ), and wildtype (WT) mice during the first two postnatal weeks.
Keywords:
PRKOdevelopmentprogesterone receptorsensorimotor behaviorsomatosensory cortex

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Last Updated: May 8, 2026

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Main Results:

  • PR expression patterns were analyzed in the developing mouse cortex.
  • PRKO and HZ mice exhibited an earlier loss of the rooting reflex compared to WT mice (2-3 days earlier).
  • No significant differences were observed between genotypes in most other assessed aspects.

Conclusions:

  • This study provides the first developmental behavioral assessment of PRKO mice.
  • PR expression appears critical for the maturation of cortical connectivity.
  • Progesterone receptor signaling is suggested to play an important role in sensorimotor integration during early development.