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Related Concept Videos

Flow Cytometry01:23

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

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Updated: May 8, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

New horizons in platelets flow cytometry.

Muhammad Saboor1, Moinuddin Moinuddin, Samina Ilyas

  • 1Baqai Institute of Hematology, Baqai Medical University, 51 Deh Tor Gadap Road, Super Highway, Near Toll Plaza, P.O Box 2407, P. Code 74600, Karachi, Pakistan.

The Malaysian Journal of Medical Sciences : MJMS
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

Platelet flow cytometry offers a reliable, cost-effective method to assess platelet activation and receptor expression. This technique aids in diagnosing platelet disorders and predicting thromboembolism risk in various conditions.

Keywords:
CD62CD63flow cytometryplatelets

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Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
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Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

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Last Updated: May 8, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

Area of Science:

  • Hematology
  • Immunology
  • Biotechnology

Background:

  • Platelet flow cytometry is an emerging diagnostic and therapeutic tool in hematology.
  • It enables detailed study of platelet surface receptor expression (qualitative and quantitative).
  • It serves as a marker for in vivo platelet activation, crucial for risk assessment.

Purpose of the Study:

  • To highlight the utility of platelet flow cytometry in hematology.
  • To demonstrate its role in diagnosing platelet disorders and predicting thromboembolic risk.
  • To showcase its application in evaluating antiplatelet drug efficacy and understanding platelet interactions.

Main Methods:

  • Utilizing flow cytometry to analyze platelet surface receptors and activation markers.
  • Quantifying platelet surface receptor expression.
  • Investigating platelet granule localization and interactions with leukocytes.

Main Results:

  • Platelet flow cytometry can document in vivo platelet activation, predicting thromboembolism risk in conditions like diabetes mellitus, coronary syndromes, and pre-eclampsia.
  • The technique allows for comparative studies of antiplatelet drug effects and dose-response relationships.
  • It facilitates the study of platelet-platelet and platelet-leukocyte interactions.

Conclusions:

  • Platelet flow cytometry is a simple, reliable, and cost-effective technique with broad applications in diagnosing inherited and acquired platelet disorders.
  • It aids in categorizing molecular lesions in disorders such as Bernard Soulier's disease, von Willebrand disease, Glanzman's disease, and Grey platelet syndrome by studying platelet cluster of differentiation (CD) markers.
  • This method provides insights into platelet function relevant to thromboembolic events and therapeutic interventions.