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Botanical agents for the treatment of nonmelanoma skin cancer

Jillian W Millsop1, Raja K Sivamani, Nasim Fazel

  • 1University of Utah, School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132, USA.

Dermatology Research and Practice
|August 29, 2013
PubMed

Insights

Botanicals, plant-derived compounds, show promise for preventing and treating nonmelanoma skin cancers. These agents possess antioxidant and anti-inflammatory properties, offering topical alternatives to surgery.

Area of Science:

  • Dermatology and Oncology
  • Phytochemistry
  • Cancer Prevention

Background:

  • Nonmelanoma skin cancers (NMSCs), such as basal cell carcinoma and squamous cell carcinoma, are prevalent globally and the most common cancers in the U.S.
  • Current standard treatment for cutaneous neoplasms is surgical excision.
  • There is growing interest in topical botanical agents for NMSC prevention and treatment, especially for superficial types.

Purpose of the Study:

  • To review botanical agents investigated for the treatment and prevention of nonmelanoma skin cancers.
  • To explore the potential of plant-derived compounds as alternatives to conventional therapies.
  • To highlight the properties of botanicals relevant to cancer chemoprevention.

Main Methods:

  • Literature review of studies on botanical agents for NMSC.
  • Analysis of research on the properties of botanicals, including antioxidant, anti-inflammatory, and immunomodulatory effects.
  • Identification of specific plant-derived compounds studied for NMSC prevention and treatment.

Main Results:

  • Botanicals possess properties like antioxidant and anti-inflammatory activity, suggesting chemopreventive potential.
  • These plant-derived compounds may help suppress or reverse carcinogenesis.
  • Review covers various botanical agents studied for their efficacy in NMSC.

Conclusions:

  • Botanical agents are being explored as promising topical alternatives for NMSC management.
  • The antioxidant, anti-inflammatory, and immunomodulatory properties of botanicals support their role in cancer prevention.
  • Further research into botanical therapies could lead to novel strategies for nonmelanoma skin cancer.

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