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Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...

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Updated: May 8, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Alternative splicing programs in prostate cancer.

Claudio Sette1

  • 1Department of Biomedicine and Prevention, University of Rome "Tor Vergata," 00133 Rome, Italy ; Laboratory of Neuroembryology, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy.

International Journal of Cell Biology
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

Alternative splicing generates diverse mRNA variants, contributing to prostate cancer (PCa) heterogeneity and treatment resistance. Understanding these splicing changes offers new diagnostic and therapeutic strategies for PCa.

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Last Updated: May 8, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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11:48

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Published on: October 9, 2014

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer (PCa) is a leading cause of cancer death in men.
  • Initial antiandrogenic therapies are often overcome by treatment-resistant PCa.
  • Cancerous cells exhibit genetic and phenotypic heterogeneity, complicating treatment.

Purpose of the Study:

  • To review the role of alternative splicing in prostate cancer (PCa) biology.
  • To highlight key genes and their alternatively spliced variants in PCa.
  • To explore the potential of alternative splicing as a diagnostic and therapeutic target.

Main Methods:

  • Literature review of studies on alternative splicing in prostate cancer.
  • Analysis of gene expression and protein isoform data.
  • Discussion of clinical implications of alternative splicing findings.

Main Results:

  • Alternative splicing contributes significantly to PCa's genetic and phenotypic heterogeneity.
  • Key genes, including the androgen receptor and cyclin D1, produce functionally distinct protein isoforms via alternative splicing.
  • Aberrant splicing patterns are observed in both normal and cancerous prostate cells.

Conclusions:

  • Alternative splicing is a critical mechanism driving prostate cancer progression and therapeutic resistance.
  • Targeting alternative splicing pathways presents a promising avenue for novel PCa diagnostics and therapeutics.
  • Further research into PCa splicing variants can improve patient outcomes.