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Related Experiment Video

Updated: May 8, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

SSRI-induced coagulopathy: is it reality?

Riyaz Siddiqui, Sushil Gawande, Tanaji Shende

Therapeutic Advances in Psychopharmacology

|August 29, 2013

Summary

This summary is machine-generated.

Fluoxetine, used for major depression, may increase bleeding time, while escitalopram shows no effect on coagulation. Both antidepressants are deemed safe for long-term use in patients with depression.

Keywords:

SSRI coagulopathy escitalopram fluoxetine

Related Experiment Videos

Last Updated: May 8, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Area of Science:

Pharmacology
Psychiatry
Hematology

Background:

Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for major depressive disorder.
Potential effects of SSRIs on coagulation parameters require thorough investigation for patient safety.

Purpose of the Study:

To evaluate the impact of escitalopram and fluoxetine on the coagulation profile of patients diagnosed with major depressive disorder.

Main Methods:

A prospective, open-label study involving 40 patients with major depressive disorder.
Patients received either escitalopram (10 mg/day) or fluoxetine (20 mg/day) for 3 months.
Coagulation parameters (bleeding time, clotting time, platelet count, prothrombin time, partial thromboplastin kaolin time) were assessed at baseline and after 3 months.

Main Results:

Fluoxetine treatment resulted in a statistically significant increase in bleeding time, although values remained within the normal range.
Escitalopram treatment did not show any significant effect on bleeding time or other coagulation parameters.
No significant changes were observed in clotting time, platelet count, prothrombin time, or partial thromboplastin kaolin time for either drug group.

Conclusions:

Fluoxetine may prolong bleeding time in patients with major depression, whereas escitalopram does not appear to affect the coagulation profile.
Both escitalopram and fluoxetine are considered safe for long-term management of depression concerning coagulation parameters.