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CNS Stimulants: Psychedelic Agents01:22

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
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Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
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Published on: September 1, 2011

Hallucinogen-persisting perception disorder.

Leo Hermle1, Melanie Simon, Martin Ruchsow

  • 1Department of Psychiatry, Christophsbad, Göppingen, Germany.

Therapeutic Advances in Psychopharmacology
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

Hallucinogen-persisting perception disorder (HPPD) symptoms, including visual disturbances, can be effectively treated with lamotrigine. This antiepileptic medication offers a promising new therapeutic approach for managing HPPD.

Keywords:
FlashbackLSDhallucinogen-persisting perception disorder

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Hallucinogen-persisting perception disorder (HPPD) is a condition characterized by persistent visual disturbances after hallucinogen use.
  • Lysergic acid diethylamide (LSD) is a potent hallucinogen that can trigger HPPD.
  • Standard treatments for HPPD, including antidepressants and antipsychotics, have shown limited efficacy.

Purpose of the Study:

  • To investigate the potential of lamotrigine, an antiepileptic drug, in treating HPPD.
  • To evaluate the effectiveness of lamotrigine in alleviating complex visual disturbances associated with HPPD.

Main Methods:

  • A case study of a 33-year-old female patient with HPPD following a year of LSD abuse.
  • The patient reported various visual symptoms, including afterimages, peripheral visual disturbances, and altered perception of size.
  • Treatment involved the administration of lamotrigine after prior treatments failed.

Main Results:

  • Lamotrigine treatment led to a significant reduction in the patient's complex visual disturbances.
  • Symptoms such as afterimages, peripheral visual effects, and macro/micropsia receded almost completely.
  • The patient experienced substantial relief from HPPD symptoms with lamotrigine therapy.

Conclusions:

  • Lamotrigine demonstrates potential as a novel therapeutic agent for managing HPPD.
  • The neuroprotective and mood-stabilizing properties of lamotrigine may underlie its efficacy in treating HPPD.
  • Further research is warranted to confirm lamotrigine's role in HPPD treatment.