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Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Does fundus fluorescein angiography procedure affect ocular pulse amplitude?
Gökhan Pekel1, Semra Acer, Ramazan Yagci
1Ophthalmology Department, Pamukkale University, 20070 Denizli, Turkey.
Journal of Ophthalmology
|August 29, 2013
Summary
Fundus fluorescein angiography (FFA) did not significantly affect ocular pulse amplitude (OPA) or intraocular pressure (IOP) in patients with nonproliferative diabetic retinopathy. Measurements showed a slight, non-statistically significant decrease in both OPA and IOP post-procedure.
Area of Science:
- Ophthalmology
- Medical Imaging
- Diabetic Retinopathy Research
Background:
- Diabetic retinopathy is a leading cause of vision loss.
- Fundus fluorescein angiography (FFA) is a common diagnostic tool for evaluating retinal vascular diseases.
- The potential impact of FFA on ocular hemodynamics, specifically intraocular pressure (IOP) and ocular pulse amplitude (OPA), requires investigation.
Purpose of the Study:
- To investigate the acute effects of the fundus fluorescein angiography (FFA) procedure on ocular pulse amplitude (OPA) and intraocular pressure (IOP).
- To determine if FFA causes statistically significant changes in OPA and IOP in patients with nonproliferative diabetic retinopathy.
Main Methods:
- A cross-sectional case series involving 30 patients (60 eyes) with nonproliferative diabetic retinopathy.
- Ocular pulse amplitude (OPA) and intraocular pressure (IOP) were measured using a Pascal dynamic contour tonometer.
- Measurements were taken before and 5 minutes after the intravenous injection of fluorescein dye for FFA.
Main Results:
- The mean OPA before FFA was 3.05 ± 1.36 mmHg, and after FFA, it was 2.93 ± 1.28 mmHg (P = 0.071).
- The mean IOP before FFA was 17.97 ± 1.99 mmHg, and after FFA, it was 17.81 ± 2.22 mmHg (P = 0.407).
- Neither the change in OPA nor the change in IOP reached statistical significance.
Conclusions:
- The fundus fluorescein angiography (FFA) procedure does not induce a statistically significant change in ocular pulse amplitude (OPA) or intraocular pressure (IOP).
- These findings suggest that FFA is safe concerning acute hemodynamic changes within the eye in patients with nonproliferative diabetic retinopathy.
- Further research may explore long-term effects or effects in different patient populations.
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