Related Experiment Video
Updated: May 8, 2026
07:30
Learning Modern Laryngeal Surgery in a Dissection Laboratory
Published on: March 18, 2020
Laryngeal synovial sarcoma: a rare clinical entity
Clair Saxby1, Ron Bova, Melanie Edwards
1St Vincents Hospital, Sydney, NSW 2010, Australia.
Case Reports in Otolaryngology
|August 29, 2013
Summary
This case report details a rare instance of biphasic synovial sarcoma (SS) in the larynx of a young male. Prompt diagnosis and a multidisciplinary treatment approach led to a successful outcome with no evidence of disease.
Area of Science:
- Oncology
- Pathology
Background:
- Synovial sarcomas (SS) are aggressive malignant soft tissue tumors originating from pluripotent mesenchymal cells.
- Laryngeal synovial sarcoma is an exceptionally rare entity with limited understanding of its clinical behavior.
Purpose of the Study:
- To report a case of biphasic synovial sarcoma in the supraglottic larynx.
- To highlight the diagnostic and therapeutic challenges associated with laryngeal SS.
- To emphasize the importance of a multidisciplinary approach in managing rare cancers.
Main Methods:
- Clinical presentation of a 20-year-old male with acute respiratory stridor.
- Diagnostic imaging (CT scan) confirming a laryngeal mass.
- Surgical intervention including total laryngectomy, hemithyroidectomy, and neck dissection.
- Adjuvant chemotherapy and radiotherapy.
Main Results:
- A diagnosis of biphasic synovial sarcoma of the larynx was established.
- The patient underwent successful surgical resection and adjuvant therapy.
- The patient remains alive and disease-free at 18 months post-treatment.
Conclusions:
- Laryngeal synovial sarcoma is a rare and challenging diagnosis.
- A multidisciplinary treatment strategy involving surgery, chemotherapy, and radiotherapy is crucial.
- Long-term follow-up is imperative for patients with laryngeal SS.
Related Concept Videos
01:21Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
01:26Esophageal Strictures-II: Clinical Features and Management
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
01:28Esophageal Varices-II: Clinical Features and Management
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
01:28Esophageal Perforation-II: Clinical Manifestations and Management
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
01:21Larynx
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...