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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Necrolytic migratory ulceration.

Jaheersha Pakran¹, Najeeba Riyaz

¹Department of Dermatology, MIMS Hospital, Calicut, Kerala, India.

Indian Dermatology Online Journal

|August 29, 2013

Summary

This summary is machine-generated.

A rare case of pancreatic cancer presented with unique skin ulcers, mimicking necrolytic migratory erythema. These migratory ulcers, a potential new paraneoplastic sign, responded to zinc and octreotide before the patient

Keywords:

Migratory ulcers necrolytic erythema necrolytic migratory erythema pancreatic tumor

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Area of Science:

Endocrinology
Oncology
Dermatology

Background:

Gastroenteropancreatic endocrine tumors are rarely associated with skin conditions.
Necrolytic migratory erythema (NME) is a known skin manifestation linked to certain tumors.

Observation:

A 53-year-old female presented with migratory annular and arcuate limb ulcers.
Histopathology suggested a link to the necrolytic erythema family.
Initial CT scans were normal, but later revealed pancreatic tail masses.

Findings:

The patient's skin lesions improved with zinc sulfate and octreotide.
The ulcers were deep, migratory, and healed with scarring, differing from typical NME.
The case suggests a novel paraneoplastic syndrome, 'necrolytic migratory ulceration', associated with pancreatic malignancy.

Implications:

This case highlights a potentially new paraneoplastic manifestation of pancreatic cancer.
Early recognition of such skin findings may aid in diagnosing underlying malignancies.
Further research is needed to understand the pathogenesis and clinical significance of necrolytic migratory ulceration.