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Published on: December 15, 2011
Celiac disease and autoimmune-associated conditions
1Gastroenterology Unit, Central University Hospital of Asturias, Celestino Villamil, 33006 Oviedo, Principality of Asturias, Spain.
Biomed Research International
|August 29, 2013
Summary
Celiac disease (CD) is a systemic autoimmune disorder with gluten intolerance. Associated conditions often manifest beyond the gut, but a gluten-free diet (GFD) can improve overall health and disease progression.
Area of Science:
- Immunology
- Gastroenterology
- Endocrinology
Background:
- Celiac disease (CD) is an autoimmune disorder characterized by gluten intolerance, presenting as a systemic condition with extradigestive manifestations.
- Diagnosis of atypical and asymptomatic CD cases, particularly in adults, has increased, highlighting the disease's broader clinical spectrum.
- Associated diseases, some sharing genetic or pathogenic links (e.g., type 1 diabetes mellitus), underscore CD's systemic nature.
Purpose of the Study:
- To emphasize that celiac disease is a systemic autoimmune disorder, not limited to the gastrointestinal tract.
- To highlight the importance of recognizing extradigestive and associated illnesses in celiac disease diagnosis and management.
- To discuss the impact of a gluten-free diet (GFD) on celiac disease and its associated conditions.
Main Methods:
- Review of current understanding of celiac disease as a systemic autoimmune disorder.
- Analysis of the relationship between celiac disease and various associated extradigestive manifestations.
- Evaluation of the effects of a gluten-free diet on the clinical course of celiac disease and related conditions.
Main Results:
- Celiac disease frequently presents with extradigestive symptoms, indicating its systemic autoimmune nature.
- Associated diseases, including type 1 diabetes mellitus, can occur alongside celiac disease due to shared genetic or pathogenic factors.
- A gluten-free diet (GFD) can improve celiac disease symptoms, resolve some associated conditions like iron deficiency anemia, and better manage others like type 1 diabetes mellitus.
Conclusions:
- Celiac disease is a systemic autoimmune disorder with diverse extradigestive manifestations.
- Early diagnosis and adherence to a gluten-free diet are crucial for managing celiac disease and its associated conditions.
- The gluten-free diet positively influences the clinical course of celiac disease and can slow the progression of associated illnesses.
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