Related Experiment Video
Updated: May 8, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
IL-17 in the rheumatologist's line of sight
Marie-Elise Truchetet1, M Djavad Mossalayi, Katia Boniface
1UMR-CNRS 5164, Composantes Innées de la Réponse Immunitaire et de la Différenciation, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux, France. marie-elise.truchetet@chu-bordeaux.fr
Abstract:
Over the past decades, the identification of several new cytokines, including interleukin (IL)-17 and IL-23, and of new T helper cell subsets, including Th17 cells, has changed the vision of immunological processes. The IL-17/Th17 pathway plays a critical role during the development of inflammation and autoimmunity, and targeting this pathway has become an attractive strategy for a number of diseases. This review aims to describe the effects of IL-17 in the joint and its roles in the development of autoimmune and inflammatory arthritis. Furthermore, biotherapies targeting directly or indirectly IL-17 in inflammatory rheumatisms will be developed.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
The JAK-STAT Signaling Pathway
Rheumatic Heart Disease I: Introduction