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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Published on: March 16, 2018

INF- α and ototoxicity.

Mohammad Reza Sharifian1, Shima Kamandi, Hamid Reza Sima

  • 1Otorhinolaryngology-Head & Neck Surgery Department, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9137913316, Iran.

Biomed Research International
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

Interferon-alfa (INF-α) treatment for hepatitis B and C may cause hearing loss. This study found significant changes in high-frequency hearing and otoacoustic emissions, suggesting ototoxicity in patients receiving INF-α.

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Area of Science:

  • Otolaryngology
  • Hepatology
  • Pharmacology

Background:

  • Interferon-alfa (INF-α) is a standard treatment for hepatitis B and C.
  • Potential ototoxic effects of INF-α are not well-documented.

Purpose of the Study:

  • To investigate the ototoxic effects of INF-α in patients treated for hepatitis B and C.
  • To evaluate changes in hearing function before and after INF-α treatment.

Main Methods:

  • A before-after control study included 24 patients receiving INF-α and 30 controls.
  • Ototoxicity was assessed using questionnaires, high-frequency audiometry, and transiently evoked otoacoustic emissions (TEOAEs).
  • Evaluations were conducted one week before and one month after INF-α prescription.

Main Results:

  • Significant hearing loss was detected in the 4000 to 8000 Hz range after treatment (P = 0.083).
  • Progressive decreases in otoacoustic emission amplitudes were observed in 41.66% (1 kHz), 18.75% (2 kHz), and 43.75% (4 kHz).
  • Hearing loss was more pronounced in older male patients.

Conclusions:

  • INF-α demonstrates ototoxicity, evidenced by high-frequency hearing impairment and reduced otoacoustic emissions.
  • Hearing monitoring is recommended for patients undergoing INF-α therapy.
  • Further research into INF-α's ototoxic mechanisms is warranted.