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Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Mismatch Repair01:36

Mismatch Repair

Overview
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Homologous Recombination02:31

Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
Restriction Enzymes01:11

Restriction Enzymes

Restriction enzymes are bacterial enzymes used to cut DNA in a sequence-specific manner. To cleave DNA, they bind to specific palindromic sequences called restriction sites. Such palindromic DNA sequences or inverted repeats are commonly found in regions of functional significance, such as the origin of replication, gene operator sites, and regions containing transcription termination signals.
The host bacteria protect their own genomic DNA from these enzymes by methylating these sites. Some...

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Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

HyDEn: a hybrid steganocryptographic approach for data encryption using randomized error-correcting DNA codes.

Dan Tulpan1, Chaouki Regoui, Guillaume Durand

  • 1National Research Council Canada, 100 des Aboiteaux Street, Moncton, NB, Canada E1A 7R1. dan.tulpan@nrc-cnrc.gc.ca

Biomed Research International
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a hybrid DNA encryption (HyDEn) method using error-correcting DNA Hamming codes for secure data encoding. HyDEn offers robust data protection and error correction, outperforming current cryptographic techniques.

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Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Area of Science:

  • Bioinformatics
  • Cryptography
  • Computational Biology

Background:

  • Current encryption methods face evolving security challenges.
  • DNA-based cryptography offers a novel paradigm for data security.
  • Error-correction mechanisms are crucial for reliable DNA data encoding.

Purpose of the Study:

  • To introduce a novel hybrid DNA encryption (HyDEn) approach.
  • To leverage error-correcting DNA Hamming codes for enhanced security.
  • To evaluate HyDEn's performance against existing cryptographic methods.

Main Methods:

  • Utilizing randomized assignments of unique DNA Hamming code words for extended ASCII characters.
  • Employing custom-built quaternary codes and a private key for randomized encoding.
  • Implementing cyclic permutations on the encoded message for added security.

Main Results:

  • HyDEn demonstrates effective data encryption using DNA sequences.
  • The approach incorporates robust error detection and correction capabilities.
  • Performance analysis shows HyDEn equals or surpasses existing cryptographic methods.

Conclusions:

  • HyDEn presents a promising in silico DNA steganographic approach.
  • The method offers a secure and reliable alternative for data encryption.
  • This research advances the field of DNA-based cybersecurity.