[Design, synthesis and antitumor activity of valproic acid salicylanilide esters]
Ming Yuan1, Jia-Ming Li, Guang-Wei He
1Department of Pharmacy, AnHui University of Chinese Medicine, AnHui Key Laboratory of Traditional Chinese Medicine, Hefei 230031, China.
Abstract:
A series of valproic acid salicylanilide esters were designed and synthesized based on the principle of prodrug. The structures of the target compounds were confirmed by MS, 1H NMR and 13C NMR. Anti-tumor activities of these compounds against K562, A549, A431 cells in vitro were investigated by MTT assay and SRB assay. The results indicated that the compounds 6h-6j were found to have stronger cell growth inhibitory action than gefitinib, and comparable to niclosamide, which are worth to be intensively studied further.
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