The miRNA world of polyomaviruses

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MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

Ole Lagatie1, Luc Tritsmans, Lieven J Stuyver

  • 1Janssen Diagnostics, Turnhoutseweg 30, Beerse 2340, Belgium. olagatie@its.jnj.com.

Virology Journal
|August 30, 2013
PubMed

Insights

Polyomaviruses, often latent, can cause disease upon reactivation. This review details viral microRNAs (miRNAs) and host miRNAs impacting polyomavirus infection, replication, and pathogenesis.

Area of Science:

  • Virology
  • Molecular Biology
  • Genetics

Background:

  • Polyomaviruses are non-enveloped DNA viruses with broad host ranges, typically causing asymptomatic infections.
  • These viruses can establish latency and reactivate, leading to severe diseases.
  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression by inhibiting mRNA translation.

Purpose of the Study:

  • To review the current understanding of microRNAs (miRNAs) involved in polyomavirus infections.
  • To detail viral miRNAs and their roles in regulating host and viral protein expression.
  • To provide an overview of host miRNA functions in controlling polyomavirus replication, immune evasion, and pathogenesis.

Main Methods:

  • Literature review of scientific articles on polyomaviruses and microRNAs.
  • Analysis of studies detailing viral miRNA discovery and function.
  • Synthesis of research on host miRNA interactions with polyomaviruses.

Main Results:

  • Several viral miRNAs have been identified within polyomavirus genomes.
  • Viral miRNAs play crucial roles in modulating host and viral gene expression.
  • Host miRNAs are increasingly recognized for their influence on polyomavirus lifecycle and disease.

Conclusions:

  • MicroRNAs, both viral and host-derived, are significant regulators in polyomavirus infections.
  • Understanding these miRNA interactions is key to deciphering polyomavirus pathogenesis.
  • Further research into miRNA-mediated mechanisms can inform therapeutic strategies.

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