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Updated: May 8, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
Published on: April 29, 2014
Targeting angiogenesis in renal cell carcinoma
Edwin M Posadas1, Suwicha Limvorasak, Shaleekha Sharma
1Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Urologic Oncology Program , 8700 Beverly Blvd, Los Angeles, CA 90048 , USA +1 310 423 7600 ; +1 310 659 3928 ; Edwin.Posadas@cmc.edu.
New kidney cancer therapies targeting non-VEGF signals show promise but may increase toxicity. Biomarker studies are crucial for guiding the development of these novel agents and patient selection for emerging therapies.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Renal cell carcinoma (RCC) pathogenesis involves hypoxia-inducible factor-1α (HIF-1α) signaling.
- Vascular Endothelial Growth Factor (VEGF) is a key angiogenic factor in RCC.
- The PI3K/Akt/mTOR pathway is implicated in HIF-1α activation and RCC development.
Purpose of the Study:
- To review current FDA-approved anti-angiogenic agents for RCC.
- To examine novel anti-angiogenic agents in development for RCC treatment.
Main Methods:
- Review of FDA-approved anti-angiogenic therapies for RCC.
- Analysis of emerging anti-angiogenic agents in clinical development.
Main Results:
- Current treatments focus on VEGF signaling.
- Novel agents target non-VEGFR pathways, presenting new therapeutic avenues.
Conclusions:
- Emerging therapies targeting non-VEGFR signals offer new hope for kidney cancer treatment.
- These novel agents may present increased toxicity, necessitating careful patient selection.
- Biomarker studies are essential for optimizing the development and application of these new therapies.
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Published on: November 23, 2014
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