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Updated: May 8, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
Published on: December 7, 2014
[Ruxolitinib prescription in myelofibrosis]
Richard Lemal1, Marie Robin, Aurélie Ravinet
1CHU de Clermont-Ferrand, CHU Estaing, service d'hématologie clinique adulte et de thérapie cellulaire, université d'Auvergne CREaT-EA 7283, Inserm CIC-501, 63000 Clermont-Ferrand, France.
Abstract:
Ruxolitinib is a JAK/STAT inhibitor, which has demonstrated clinical benefits in patients with intermediate-2 and high-risk myelofibrosis. Moreover, first results of recent clinical trials show a trend to better overall survival with ruxolitinib, which allows to hope that we will soon be able to change the natural evolution of this poor outcome disease. With such results, ruxolitinib quickly obtained the Food and Drug Administration (FDA) approval in the United States of America. In France, ruxolitinib is now available, allowing its administration to symptomatic myelofibrosis patients.
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