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Updated: May 8, 2026

Clinical Anthropometrics and Body Composition from 3-Dimensional Optical Imaging
Published on: June 7, 2024
Body composition from birth to 6 mo of age in Ethiopian infants: reference data obtained by air-displacement
Gregers S Andersen1, Tsinuel Girma, Jonathan C K Wells
1Steno Diabetes Center, Gentofte, Denmark.
Insights
This study provides crucial reference data for infant body composition, including fat mass (FM) and fat-free mass (FFM), in an urban African population. These findings are essential for understanding infant growth and future health outcomes.
Area of Science:
- Pediatric Nutrition
- Human Growth and Development
- Body Composition Analysis
Background:
- Infant body composition data is vital for understanding long-term disease risk.
- Limited body composition data exists for infants in low-income settings.
- New assessment techniques are available but underutilized in infant studies.
Purpose of the Study:
- To establish reference data for fat mass (FM) and fat-free mass (FFM) in infants.
- To cover the period from birth to 6 months of age.
- To focus on an urban African population.
Main Methods:
- Prospective cohort study in Jimma, Ethiopia.
- Air-displacement plethysmography (ADP) used for FM and FFM measurements.
- Lambda-mu-sigma method applied for constructing reference charts and tables.
Main Results:
- 2026 body composition measurements from 378 infants were analyzed.
- Fat mass and fat mass index (FMI) showed logarithmic growth patterns.
- Fat-free mass (FFM) exhibited near-linear growth with a slight deceleration around 3 months.
Conclusions:
- Presents the first z scores and centile reference charts for FM and FFM in an urban Ethiopian infant population.
- Provides essential reference data for African infants, aiding clinical care and research.
- Highlights the importance of context-specific body composition data.
Background:
Data on body composition in infancy may improve the understanding of the relation between variability in fetal and infant growth and disease risk through the life course. Although new assessment techniques have recently become available, body composition is rarely described in infants from low-income settings.
Objective:
The aim of this study was to provide reference data for fat mass (FM) and fat-free mass (FFM) from birth to the age of 6 mo from an urban African population.
Design:
We conducted a prospective cohort study among infants from Jimma, Ethiopia. FM and FFM were measured at birth and at 1.5, 2.5, 3.5, 4.5, and 6 mo of age with air-displacement plethysmography (ADP) validated against a stable isotope method in a subsample. Reference charts and reference tables with z scores and percentiles for FM, FFM, FM index (FMI; in kg/m(2)), and FFM index (FFMI: in kg/m(2)) were constructed with the lambda-mu-sigma method.
Results:
Body composition growth charts were based on a total of 2026 measurements of body composition obtained from 378 infants. FM and FMI gain progressed in a logarithmic-shaped curve and variation increased with increasing age, whereas FFM increased in an almost linear manner with a minor deceleration at around 3 mo of age. The FFMI curve showed a very modest exponential increase with age.
Conclusions:
By presenting z scores and centile reference charts for an apparently healthy urban Ethiopian infant population, this study represents a first step toward providing reference data on FM and FFM for an urban African context, which is important for future clinical care and research. This study was registered at www.controlled-trials.com as ISRCTN46718296.
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