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Calamine lotion: experimenting with a new suspending agent.
A Al-Achi1, R Greenwood, A Akin-Isijola
1Campbell University School of Pharmacy, Buies Creek, NC 27506.
International Journal of Pharmaceutical Compounding
|August 30, 2013
Summary
Tahini, a sesame paste, can effectively replace bentonite magma as a suspending agent in calamine lotion. This study found tahini improved the physical stability of calamine lotion formulations.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Calamine lotion, a common topical treatment, utilizes bentonite magma as its suspending agent.
- The need for alternative suspending agents in pharmaceutical formulations is ongoing.
Purpose of the Study:
- To investigate the efficacy of tahini as a novel suspending agent in calamine lotion.
- To evaluate the impact of replacing bentonite magma with tahini on the physical stability and rheological properties of calamine lotion.
Main Methods:
- Calamine lotion formulations were prepared using varying percentages (25% to 100%) of tahini as a replacement for bentonite magma.
- Sedimentation volume and degree of flocculation were measured to assess physical stability.
- Rheological characteristics were determined for all prepared suspensions.
Main Results:
- Lotions with 100% tahini showed a significantly higher sedimentation volume (0.851) compared to 100% bentonite (0.723).
- The degree of flocculation was also higher in 100% tahini formulations (2.35) versus 100% bentonite (2.00).
- All tested calamine lotion suspensions exhibited pseudoplastic flow.
Conclusions:
- Tahini demonstrates potential as an effective suspending agent in calamine lotion.
- Partial or complete replacement of bentonite magma with tahini can enhance the physical stability of calamine lotion.
- Tahini offers a promising alternative for improving topical formulation stability.
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