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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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Anti-psoriatic therapy recovers high-density lipoprotein composition and function.

Michael Holzer¹, Peter Wolf², Martin Inzinger²

¹Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.

The Journal of Investigative Dermatology

|August 30, 2013

Summary

Anti-psoriatic therapy improves high-density lipoprotein (HDL) function in psoriasis patients, enhancing cholesterol efflux. This suggests HDL function, not just HDL-cholesterol levels, is a key cardiovascular risk marker.

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Area of Science:

Cardiovascular disease
Dermatology
Lipidology

Background:

Psoriasis is linked to higher cardiovascular mortality.
Psoriasis alters high-density lipoprotein (HDL) composition, leading to dysfunctional HDL particles.
The impact of anti-psoriatic therapy on HDL function remains unclear.

Purpose of the Study:

To investigate the effect of anti-psoriatic therapy on HDL composition and function in patients with psoriasis.
To assess whether therapeutic interventions can restore HDL functionality.

Main Methods:

HDL was isolated from 15 psoriatic patients before and after treatment, and from 15 healthy controls.
Key HDL functions evaluated included cholesterol efflux capacity, paraoxonase activity, and Lp-PLA2 activity.
Changes in lecithin-cholesterol acyltransferase and lipolytic activity were also measured.

Main Results:

Psoriatic patients exhibited impaired cholesterol efflux, lower paraoxonase, and higher Lp-PLA2 activity compared to controls.
Anti-psoriatic therapy significantly improved lecithin-cholesterol acyltransferase activity and reduced lipolytic activity.
Crucially, HDL-cholesterol efflux capability was significantly enhanced post-therapy, independent of HDL-cholesterol levels.

Conclusions:

Effective anti-psoriatic therapy restores HDL composition and function in psoriasis patients.
HDL function appears to be a more sensitive marker of cardiovascular risk than HDL-cholesterol levels.
These findings support the growing understanding of HDL's role in cardiovascular health beyond simple lipid levels.