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Pemphigus. Skin failure mediated by autoantibodies
1Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
JAMA
|October 3, 1990
Summary
Pemphigus involves autoantibodies attacking skin cell adhesion, causing blisters. Research is actively investigating the precise mechanisms by which these antibodies disrupt cell junctions and skin barrier function.
Area of Science:
- Dermatology
- Immunology
- Cell Biology
Background:
- Pemphigus is a group of autoimmune blistering diseases.
- Autoantibodies in pemphigus target cell adhesion molecules in desmosomes.
- This leads to loss of keratinocyte adhesion and blister formation.