Related Experiment Video
Updated: Oct 8, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Pemphigus. Skin failure mediated by autoantibodies
1Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Abstract:
Pemphigus is a group of diseases in which autoantibodies mediate a loss of cell-to-cell adhesion, resulting in blister formation and ultimate failure of the barrier function of the skin. These autoantibodies are directed against complexes that contain polypeptides found in adhering junctions. Exactly how these antibodies mediate loss of cell adhesion, whether through secondary mechanisms such as release of proteases, direct interference of junction formation, or both, remains an area of active and exciting investigation.
Related Concept Videos
Cell-mediated Immune Responses
Desmosomes
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Drug Toxicity: Allergic Reactions
Hypersensitivity Reactions: Cytolytic Reactions
Type I Diabetes II: Pathophysiology

