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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: May 8, 2026

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
10:53

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

Pluripotent stem cells as a model to study non-coding RNAs function in human neurogenesis.

Alexandra Benchoua1, Marc Peschanski

  • 1Centre d'Etude des Cellules Souches, Institut des cellules Souches pour le Traitement et l'Étude des Maladies monogéniques, Association Française contre les Myopathies Evry, France.

Frontiers in Cellular Neuroscience
|August 30, 2013
PubMed
Summary

Human pluripotent stem cells (hPSCs) enable studying micro-RNAs (miRNAs) in early human neurodevelopment. This research explores how hPSCs model early nervous system development and miRNA roles in neurological diseases.

Keywords:
micro-RNAneuro-developmental diseasesneurogenesispluripotent stem cellspsychiatry

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Area of Science:

  • Developmental Neuroscience
  • Stem Cell Biology
  • Molecular Genetics

Background:

  • Micro-RNAs (miRNAs) are crucial regulators of gene expression, particularly in nervous system development.
  • Studying miRNA roles in early human neurogenesis is challenging due to experimental limitations in vivo.
  • Human pluripotent stem cells (hPSCs) offer a viable model for investigating early developmental processes.

Purpose of the Study:

  • To demonstrate how hPSCs can model early human neurogenesis.
  • To review the contribution of hPSCs to understanding miRNA functions in nervous system development.
  • To explore the role of miRNAs in physiological and pathological contexts of brain development.

Main Methods:

  • Utilizing robust protocols to differentiate hPSCs into various functional neuronal subtypes.
  • Recapitulating key developmental milestones of neurogenesis in vitro.
  • Analyzing the role of miRNAs in regulating phenotypic transitions during neuronal differentiation.

Main Results:

  • Established hPSC differentiation protocols effectively model early human neurogenesis.
  • hPSCs provide a platform to study miRNA-mediated regulation of neuronal development.
  • This model system is applicable to investigating neurological diseases with developmental origins.

Conclusions:

  • hPSCs are a powerful tool for studying the intricate roles of miRNAs in early human neurodevelopment.
  • Understanding miRNA functions in hPSC-derived neurons can shed light on developmental neurological disorders.
  • This approach facilitates research into brain development and plasticity, even in pathological conditions.