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Updated: May 8, 2026

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
Published on: September 16, 2020
Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis
Olga Gubar1, Dmytro Morderer, Lyudmila Tsyba
1State Key Laboratory of Molecular and Cellular Biology, Institute of Molecular Biology and Genetics , Kyiv , Ukraine ; Department of Functional Genomics, Institute of Molecular Biology and Genetics , Kyiv , Ukraine ; Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique-Unité Propre de Recherche 3212, Université de Strasbourg , Strasbourg , France.
Abstract:
Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby suggesting a role for ITSN1 in the coupling between exocytosis and endocytosis in excitatory cells. Despite a high degree of conservation amongst orthologs, ITSN function is not so well preserved as they have acquired new properties during evolution. In this review, we will discuss the role of ITSN1 and its orthologs in exo- and endocytosis, in particular in neurons and neuroendocrine cells.
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