[Modern principles of diagnosis and prediction of course of chronic obstructive pyelonephritis in children]

Related Experiment Video

Updated: May 8, 2026

Transmesenteric Laparoscopic Pyeloplasty in Trendelenburg Position for Horseshoe Kidney with Hydronephrosis
03:57

Transmesenteric Laparoscopic Pyeloplasty in Trendelenburg Position for Horseshoe Kidney with Hydronephrosis

Published on: July 8, 2025

D A Morozov, O L Morozova, N B Zakharova

    Urologiia (Moscow, Russia : 1999)
    |August 31, 2013
    PubMed

    Insights

    Urinary tract inflammation severity in congenital obstructions can be diagnosed using serum C-reactive protein and urine IL-6, IL-8 levels. A novel index using urine IL-8 and IL-10 in children tracks inflammation and treatment effectiveness.

    Area of Science:

    • Biochemistry
    • Immunology
    • Urology

    Context:

    • Congenital urinary tract obstructions (CUTOs) pose significant health challenges, often leading to complex inflammatory responses.
    • Perioperative assessment is crucial for managing patients with CUTOs and preventing complications like chronic obstructive pyelonephritis.
    • Biomarker analysis provides objective measures for inflammation severity and treatment response.

    Purpose:

    • To assess changes in cytokines, cell adhesion molecules, and acute phase proteins in patients with CUTOs.
    • To determine the diagnostic significance of specific biomarkers for inflammation severity in the urinary tract.
    • To develop and validate an inflammation activity index for monitoring treatment efficacy in pediatric patients.

    Summary:

    • Serum C-reactive protein and urinary interleukin-6 (IL-6) and interleukin-8 (IL-8) levels demonstrate high diagnostic value in assessing urinary tract inflammation severity in patients with CUTOs.
    • Urinary IL-8 and interleukin-10 (IL-10) levels were utilized to create a dynamic inflammation activity index in children, enabling estimation of inflammation phase and treatment effectiveness.
    • Enzyme-linked immunosorbent assay (ELISA) was employed to analyze serum, urine, and biopsy samples from 167 patients undergoing perioperative evaluation for various CUTOs.

    Impact:

    • This research offers valuable insights into the perioperative inflammatory landscape of CUTOs.
    • The identified biomarkers and the proposed inflammation activity index can aid clinicians in more precise diagnosis and management of urinary tract inflammation.
    • The findings contribute to improved patient outcomes through enhanced monitoring of treatment efficacy in pediatric cases.

    Related Concept Videos

    Acute Pyelonephritis II: Diagnostic Studies and Management01:28

    Acute Pyelonephritis II: Diagnostic Studies and Management

    Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
    Acute Pyelonephritis I: Introduction01:27

    Acute Pyelonephritis I: Introduction

    Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
    Urinary Tract Infection II: Pathophysiology01:25

    Urinary Tract Infection II: Pathophysiology

    The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
    Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

    Acute Kidney Injury IV: Diagnostic Studies and Prevention

    Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
    Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

    Imaging Studies V: Intravenous Urography and Retrograde Pyelography

    IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
    Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

    Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

    A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...