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Activation of Integrins

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Integrins

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: May 8, 2026

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

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[Integrins as a potential target for targeted anticancer therapy].

A E Berman, N I Kozlova, G E Morozevich

Biomeditsinskaia Khimiia

|August 31, 2013

Summary

This review covers integrin structure and their role in tumor development and progression. It highlights therapeutic strategies targeting integrin function for cancer treatment with clinical potential.

Area of Science:

Molecular Biology
Oncology
Biochemistry

Context:

Integrins are crucial cell surface receptors mediating cell-matrix and cell-cell interactions.
Their dysregulation is implicated in various stages of tumor development and malignant progression.
Understanding integrin structure and function is key to developing targeted cancer therapies.

Purpose:

To review the structure of integrins and their specific roles in tumor initiation and advancement.
To explore therapeutic strategies focused on modifying integrin activity to inhibit cancer growth.
To assess the clinical applicability of these novel anti-integrin approaches.

Summary:

The review details integrin structure and their involvement in tumor development and malignant progression.

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It emphasizes therapeutic strategies that modify integrin functional properties to antagonize tumor growth.

These experimental approaches show promise for clinical applications in cancer treatment.

Impact:

Provides a comprehensive overview of integrins in cancer biology.
Highlights innovative therapeutic avenues for cancer treatment.
Suggests potential for clinical translation of integrin-targeted therapies.