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Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging
Qian Yin1, Felix Y Yap, Lichen Yin
1Department of Materials Science and Engineering, §Department of Veterinary Clinical Medicine, and ⊥Department of Bioengineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Abstract:
Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.
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