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Hypothyroidism as a cause of enzyme elevations
Journal of the South Carolina Medical Association (1975)
|June 1, 1990
Summary
Elevated serum enzyme levels, including CPK, SGOT, LDH, and alkaline phosphatase, can be a key indicator for diagnosing previously unrecognized hypothyroidism. These enzyme changes offer crucial diagnostic clues in clinical practice.
Area of Science:
- Biochemistry
- Endocrinology
- Clinical Diagnostics
Background:
- Hypothyroidism, a condition of insufficient thyroid hormone production, can present with diverse and sometimes subtle clinical signs.
- Serum enzyme elevations are common in various medical conditions, but their specific utility in diagnosing hypothyroidism requires further elucidation.
Observation:
- This report details three distinct cases where patients exhibited elevated levels of specific serum enzymes.
- The enzymes monitored included creatine phosphokinase (CPK), serum glutamic-oxaloacetic transaminase (SGOT), lactate dehydrogenase (LDH), and alkaline phosphatase.
Findings:
- In all three reported cases, the elevated serum enzyme levels served as a significant diagnostic clue.
- These biochemical abnormalities pointed towards the presence of previously unrecognized hypothyroidism.
Implications:
- The findings suggest that routine monitoring of these serum enzymes may aid in the early detection of hypothyroidism.
- Clinicians should consider hypothyroidism in the differential diagnosis when faced with unexplained elevations in CPK, SGOT, LDH, or alkaline phosphatase.
- This highlights the importance of a comprehensive biochemical workup in diagnosing endocrine disorders.