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Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
Published on: August 19, 2015
Pectin/carboxymethyl cellulose/microfibrillated cellulose composite scaffolds for tissue engineering.
Neethu Ninan1, Muthunarayanan Muthiah, In-Kyu Park
1Université de Bretagne Sud, Laboratoire Ingénierie des Matériaux de Bretagne, BP 92116, 56321 Lorient Cedex, France. neethuninan85@yahoo.co.in
Carbohydrate Polymers
|August 31, 2013
Summary
Novel biopolymer scaffolds using pectin, carboxymethyl cellulose (CMC), and microfibrillated cellulose (MFC) show enhanced mechanical properties and biocompatibility for tissue engineering. The optimized scaffold (C(0.1%)) demonstrates excellent thermal stability and cell viability.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Highly porous three-dimensional scaffolds are crucial for tissue engineering.
- Biopolymer-based scaffolds offer biocompatibility and tunable properties.
Purpose of the Study:
- To synthesize and characterize novel composite scaffolds using pectin, CMC, and MFC.
- To evaluate the mechanical, thermal, and biological properties of the developed scaffolds for tissue engineering applications.
Main Methods:
- Scaffolds were synthesized using the lyophilisation technique.
- Characterization included mechanical testing (compression modulus), thermal analysis (glass transition temperature), micro computed tomography (porosity), XRD, FTIR, water uptake, in vitro degradation studies, and cell viability assays (NIH3T3 fibroblast).
Main Results:
- The optimized scaffold C(0.1%) (0.1% MFC) exhibited a high compression modulus (~3.987 MPa) and glass transition temperature (~103 °C).
- Porosity was measured at 88% with reduced pore size (10-250 μm) compared to the control (30-300 μm).
- C(0.1%) demonstrated excellent thermal stability, lower degradation rate, controlled water uptake, and highest cell viability.
Conclusions:
- The pectin/CMC/MFC composite scaffolds possess desirable properties for tissue engineering.
- The optimized scaffold C(0.1%) shows significant potential for use in regenerative medicine due to its mechanical strength, stability, and biocompatibility.
