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Updated: May 8, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
ent-Labdane diterpenes from the stems of Mallotus japonicus
De-Zheng Li1, Chunping Tang, Ronald J Quinn
1State Key Laboratory of Drug Research & SIMM-CUHK Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Abstract:
Eight new ent-labdane diterpenoids, mallonicusins A-H (1-8), were isolated from the stems of Mallotus japonicus. Their structures, including the absolute configurations, were determined by extensive analyses of spectroscopic data and the ECD spectra of the Pr(FOD)₃ complex of substrates in CCl₄. The absolute configuration of compound 1 was confirmed by single-crystal X-ray crystallography using Cu Kα radiation.
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